Fig. 2: Case-control differences of regional morphometric similarities. | Nature Communications

Fig. 2: Case-control differences of regional morphometric similarities.

From: Cortical structural differences in major depressive disorder correlate with cell type-specific transcriptional signatures

Fig. 2

a Mean regional morphometric similarity network (MSN) pattern of control subjects and individuals with MDD. The frontal and temporal lobes exhibited high MSN values, whereas the occipital and somatosensory cortices showed low MSN values. b Case-control comparison (t-map) of regional MSN (first row, unthresholded). Seven cortical regions showed statistically significant differences (bottom row, pFDR < 0.05). c A scatterplot of the mean regional MSN (x-axis) and case-control t-map (y-axis) (first row) (Pearson’s r(306) = −0.71, pspin = 0.00). p value was not corrected for multiple comparisons, and was determined based on a one-sided test. Most cortical regions exhibited dedifferentiation (34%) and decoupling (41%) in individuals with MDD (bottom row).

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