Fig. 3: Gene expression profiles related to morphometric similarity differences.
a Changes in regional morphometric similarity network (MSN) in the left hemisphere (unthresholded). b A weighted gene expression map of regional PLS1 scores in the left hemisphere (unthresholded). c A scatterplot of regional PLS1 scores (a weighted sum of 10,027 gene expression scores) and regional changes in MSN (Pearson’s r(150) = 0.60, pspin = 0.00). p value was not corrected for multiple comparisons, and was determined based on a one-sided test. d Ranked PLS1 loadings. e MDD-related genes from in situ hybridization in the adult human brain positively (i.e., ADRA2A: Pearson’s r(150) = 0.21, adjusted pspin = 0.04; CHRM2: Pearson’s r(150) = 0.40, adjusted pspin = 0.003; CUX2: Pearson’s r(150) = 0.50, adjusted pspin = 0.001; HTR5A: Pearson’s r(150) = 0.19, adjusted pspin = 0.14) and negatively (i.e., CNR1: Pearson’s r(150) = −0.43, adjusted pspin = 0.007; CRH: Pearson’s r(150) = −0.09, adjusted pspin = 0.28; GAD2: Pearson’s r(150) = −0.01, adjusted pspin = 0.43; HTR1A: Pearson’s r(150) = −0.38, adjusted pspin = 0.01; MAOA: Pearson’s r(150) = −0.11, adjusted pspin = 0.25; PDE1A: Pearson’s r(150) = −0.33, adjusted pspin = 0.03; SST: Pearson’s r(150) = −0.38, adjusted pspin = 0.04; TAC1: Pearson’s r(150) = −0.53, adjusted pspin = 0.001) correlated with regional changes in MSN. All p values were derived from spin tests and adjusted by FDR, and were determined based on one-sided tests. The asterisk represents p values that survived after FDR-corrected with p < 0.05.
