Fig. 5: PLGA-NB delivery system can suppress TGFβ signaling after wound closure to inhibit skin scarring. | Nature Communications

Fig. 5: PLGA-NB delivery system can suppress TGFβ signaling after wound closure to inhibit skin scarring.

From: A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing

Fig. 5

A-F Quantification of TβRI (A), SMAD2 (B), SMAD3 (C), F4/80 (macrophage marker) (D), CD4 (E), and α-SMA (F) positive cells in skin after treatment of PLGA capsules loaded with TGFβ inhibitor. n = 5 independent samples. Data are presented as mean ± SD. p values for representative data are shown (One-tailed paired Student’s t-test). G Primary skin keratinocytes were transduced with vector encoding SBE-luciferase reporter. Bioluminescence activity was measured upon different stimulations. n = 3 independent samples. Data are presented as mean ± SD. H Intravital bioluminescent imaging of nude mice receiving skin grafts with expression of SBE-luciferase reporter. I Fold changes of bioluminescence signals after skin wounding upon treatment with PLGA capsules or PLGA capsules loaded with TGFβ inhibitor. n = 3 independent samples. Data are presented as mean ± SD. All error bars represent SD. Source data are provided as a Source Data file.

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