Fig. 6: Cell death is increased by G592R Kv3.3. | Nature Communications

Fig. 6: Cell death is increased by G592R Kv3.3.

From: Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1

Fig. 6

a Quantification of propidium iodide staining in untransfected CHO cells and cells expressing wild type or G592R Kv3.3 channels (n = 3 dishes; data are presented as mean ± SEM; two-tailed unpaired t test). b Western blots showing levels of cleaved caspase 7 in the three groups of cells and in G592R Kv3.3 cells pretreated with the TBK1 inhibitor 10 µM MRT67307. c Group data for b (n = 5 independent experiments; data are presented as mean ± SEM; two-tailed paired t test). d Western blots showing the effect of overexpression of Hax-1 in G592R Kv3.3 cells on levels of cleaved caspase-7. e Group data for d (n = 4 independent experiments; data are presented as mean ± SEM, two-tailed paired t test). Source data and uncropped Western blots are provided as a Source Data file.

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