Fig. 2: MBX-4132 clears infection by a multiple-antibiotic resistant N. gonorrhoeae strain in a murine infection model. | Nature Communications

Fig. 2: MBX-4132 clears infection by a multiple-antibiotic resistant N. gonorrhoeae strain in a murine infection model.

From: trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo

Fig. 2

Mice were infected with N. gonorrhoeae H041 for two days and treated with a single oral dose of 10 mg/kg MBX-4132 or vehicle on day 0 (green arrow), (n = 20 mice for MBX-4132 and n = 21 mice for vehicle). As a positive control, 48 mg/kg gentamicin (GEN) was administered by intraperitoneal injection beginning on day 0 (5QD, black arrows). A The percentage of infected mice over 8 days post-treatment. Mice that were culture-negative for at least 3 consecutive days were considered to have cleared infection. MBX-4132 and GEN significantly reduced the percent of infected mice compared to vehicle (Mantel-Cox, p < 0.0001). B Mean bacterial burden (cfu/ml) recovered daily following treatment on day 0. MBX-4132 and GEN significantly reduced the bacterial burden compared to vehicle (2-way ANOVA with Bonferroni for multiple comparisons, p < 0.0001). Limit of detection (20 cfu/ml) is denoted by the horizontal dashed line. Error bars indicate standard error of the mean. Source data are provided as a Source Data file.

Back to article page