Fig. 3: KKL-2098 binds near the peptidyl transferase center. | Nature Communications

Fig. 3: KKL-2098 binds near the peptidyl transferase center.

From: trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo

Fig. 3

A The chemical structure of KKL-2098. B The cryo-EM structure of the E. coli 70S non-stop ribosome with P-site tRNA, mRNA, ribosomal protein bL27 and KKL-2098 indicated. C KKL-2098 is positioned close to the peptidyl transferase center adjacent to 23S rRNA A2602, C2452, U2506, and U2585 and the CCA end of the P-site tRNA. D The N terminus of bL27 (purple) moves 180° to pack against ribosomal protein uL16 and the acceptor arm of the P-site tRNA. The normal position of bL27 in translating ribosomes is shown in green (PDB 6ENU).

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