Fig. 5: Comparison of the position of KKL-2098 to other PTC inhibitors. | Nature Communications

Fig. 5: Comparison of the position of KKL-2098 to other PTC inhibitors.

From: trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo

Fig. 5

A Overview of the bacterial ribosome showing the position of sparsomycin (PDB 1NJM), chloramphenicol (PDB code 6ND5) and KKL-2098. B Inset view of the interactions of PTC nucleotides with sparsomycin. The nucleobase of 23S rRNA A2602 moves ~180° upon sparsomycin binding. KKL-2098 and A2602 in the absence of sparsomycin binding are shown in red. C Inset view of the interactions of PTC nucleotides with chloramphenicol. The nucleobase of 23S rRNA A2062 also moves ~180° upon chloramphenicol binding. KKL-2098 and A2062 in the absence of chloramphenicol binding are shown in red.

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