Fig. 6: AAV-BMPER improves glucose responses in diabetic mice.
From: Loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance
a BMPER plasma levels in C57BL/6 (WT), AAV-GFP, or AAV-BMPER (B)-injected mice that were fed HFD or CC diet. b, c Fasted insulin and glucose. d Glucose and insulin tolerance tests. e BMPER plasma levels in C57BL/6 (WT), AAV-GFP, or AAV-BMPER (B)-injected db/db mice. f, g Fasted insulin and glucose. h Glucose and insulin tolerance tests. i Urinary glucose levels. j Urinary albumin levels. k Urine volume. l Glucose and insulin tolerance tests. IR-WT, IRflox/flox; CAG-CreER–/–. IR-iKO, IRflox/flox; CAG-CreER+/–. n = 3 mice (a, e), 6–8 mice (b–d AAV-GFP), 6–8 mice (b–d AAV-BMPER), 5 mice (f, g, i–k), 5 mice (h AAV-GFP), 6–7 mice (h AAV-BMPER), 4 mice (l IR-WT;AAV-GFP, IR-iKO;AAV-GFP, IR-WT;AAV-BMPER), and 5 mice (l IR-iKO;AAV-BMPER). Data are presented as mean values ± SEM. Analysis was two-way ANOVA (for a–d, h, l) or one-way ANOVA (for e) followed by Fisher’s LSD multiple comparison test or unpaired two-tailed Student’s t test (f, g, i–k).
