Table 1 Metabolic parameters.

From: Loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance

Parameters

WT

iKO

BW (g)

32.25 ± 0.86

32.18 ± 1.05(NS)

Serum parameters

Glucose (mg/dl)

Fasted

139.0 ± 4.79

150.0 ± 3.81(NS)

Fed

174.7 ± 6.12

176.4 ± 8.134(NS)

Insulin (ng/ml)

Fasted

1.31 ± 0.13

2.80 ± 0.22 P=0.0002

Fed

2.81 ± 0.20

16.77 ± 0.42 P<0.0002

TG (mg/dl)

73.12 ± 4.25

85.78 ± 3.30 P=0.03

FFA (mEq/I)

0.78 ± 0.10

0.78 ± 0.05(NS)

Liver parameters

TG (mg/g tissue)

9.81 ± 0.65

12.44 ± 0.69 P=0.02

DAG (nmol/mg tissue)

2.14 ± 0.50

4.53 ± 0.47 P=0.006

BCAA (nmol/mg tissue)

0.44 ± 0.08

0.58 ± 0.05(NS)

Ceramide (nmol/mg tissue)

0.15 ± 0.01

0.16 ± 0.001(NS)

Skeletal muscle parameters

TG (mg/g tissue)

5.19 ± 1.31

8.99 ± 1.50(NS)

DAG (nmol/mg tissue)

0.56 ± 0.08

0.62 ± 0.09(NS)

BCAA (nmol/mg tissue)

0.23 ± 0.02

0.34 ± 0.06(NS)

Ceramide (nmol/mg tissue)

0.08 ± 0.01

0.06 ± 0.01(NS)

  1. n = 25 mice (BW, WT), 27 mice (BW, iKO), 6 mice (fasted glucose and insulin, WT), 7 mice (fasted glucose and insulin, iKO), 9 mice (fed glucose), 5 mice (fed insulin, WT), 6 mice (fed insulin, iKO), 10 mice (TG, FFA in serum), 7 mice (liver and skeletal muscle parameters, WT), 6 mice (liver parameters, iKO), and 5 mice (skeletal muscle parameters, iKO). Data are presented as mean values ± SEM. NS not significant. Analysis was unpaired two-tailed Student’s t test. WT, BMPERflox/flox;CAG-CreER–/–. iKO, BMPERflox/flox;CAG-CreER+/–.
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