Fig. 1: Survival analysis and clinical scoring of rhesus macaques challenged with MARV virus.

a Kaplan–Meier survival curves of rhesus macaques receiving treatment beginning 5 dpi and untreated and historical control animals. b Kaplan–Meier survival curves of rhesus macaques receiving treatment beginning 6 dpi and untreated and historical control animals. For (a, b), curves for the in-study control and historical control animals are shown separately; however, for statistical comparison, the in-study control was pooled with the historical controls. The reported two-tailed p value was derived from Fisher’s exact test corrected for multiple comparisons using the Hochberg method, and was rounded to four decimal places. c–e Clinical scoring for rhesus macaques with treatment initiated 6 dpi with remdesivir (c), MR186-YTE (d), and combined remdesivir/MR186-YTE (e). The horizontal dashed line represents the minimum clinical score by which euthanasia criteria was met. T_x = “treatment”. Source data are provided as a Source Data file.