Fig. 5: Encoding of locomotion in motor cortex and midbrain neurons in healthy rats. | Nature Communications

Fig. 5: Encoding of locomotion in motor cortex and midbrain neurons in healthy rats.

From: Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury

Fig. 5

a Experimental setup depicting neuronal recordings from right MI (32 channels) and left MLR (16 channels) regions, together with whole body kinematics and muscle activity. b 3D visualization of MI and MLR electrode locations, combining in all experimental rats (n = 6 rats). A-P, anteroposterior; D-V, dorso-ventral. c Stick diagram decomposition of left hindlimb movement together with EMG activity of ankle muscles and multiunit activity recorded from MI and MLR regions. d Representative channel recorded from the electrodes located in MI and MLR with locomotor-related modulation of activity. The raster displays 10 successive trials. Shaded area, s.e.m. e Normalized averaged activity from all locomotor-related MI and MLR multi-units during gait initiation. Shaded area, s.e.m. f Distribution of MI and MLR channels encoding the speed of locomotion based on their relative correlation (R2) with average speed (n = 7 rats).

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