Fig. 6: Encoding of locomotion in motor cortex and midbrain neurons in rats with SCI. | Nature Communications

Fig. 6: Encoding of locomotion in motor cortex and midbrain neurons in rats with SCI.

From: Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury

Fig. 6

a Sequence of photo showing quadrupedal locomotion after SCI, together with a stick diagram decomposition of left hindlimb movement, EMG activity of leg muscles and multiunit activity recorded from MI and MLR regions. (b) and (c) show the same representations as in Fig. 4 for recorded performed 2–3 weeks after the contusion SCI. Shaded areas, s.e.m. d Distribution of MI and MLR channels encoding the speed of locomotion based on their relative correlation (R2) with average speed (n = 6 rats). e Bar plot reporting the relative number of multi-units encoding the speed of locomotion in intact rats and after SCI (n = 6 rats, p = 0.031 paired, one-tailed Wilcoxon signed-rank test). f Bar plots reporting the mean values of the time at which the firing rates of all locomotor-related multi-units from MI and MLR crossed a threshold of 2 standard deviations above the baseline. The time is shown for all rats, before (n = 7 rats, p = 0.0001) and after SCI (n = 6, p = 0.00066). One-tailed Wilcoxon signed-rank test. *, P < 0.05; **, P < 0.01; ***, P < 0.001. Bar diagrams, mean ± s.d.

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