Fig. 2: Mutational signature landscape of multiple myeloma (MM) and myeloma precursor condition. | Nature Communications

Fig. 2: Mutational signature landscape of multiple myeloma (MM) and myeloma precursor condition.

From: Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities

Fig. 2

a Mutational signature contribution across all WGS samples included in the study. PD47563 is a patient with stable myeloma precursor condition with two samples collected at different time points, both reported in this plot (i.e., PD47563a and PD47563c). b Comparison of APOBEC mutational contribution (SBS2 + SBS13) between MM (N = 80), progressive (N = 17), and stable myeloma (N = 15) precursors. p values were calculated using Wilcoxon rank-sum test. Boxplots show the median and interquartile range. c APOBEC3A:3B ratio of all patients included in the study having detectable APOBEC activity. Blue, purple, and brown dots represent stable, progressive myeloma precursors, and MM, respectively. The green and yellow boxes on the x-axis reflect cases with and without translocations involving MAF/MAFB, respectively. MM: multiple myeloma, MGUS: monoclonal gammopathy of undetermined significance, SMM: smoldering multiple myeloma, SD: stable, PD: progressive, SBS: single-base substitution.

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