Fig. 4: Copy number profile of myeloma precursor condition and multiple myeloma (MM). | Nature Communications

Fig. 4: Copy number profile of myeloma precursor condition and multiple myeloma (MM).

From: Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities

Fig. 4

Cumulative copy number profile of all patients with either WGS or SNP array data available. Cases were grouped according to their clinical stage: stable (N = 81) and progressive (N = 19) myeloma precursor condition and MM (N = 228). Red and blue bars reflect chromosomal gain and loss, respectively. Yellow and green lines on the top of each graph represent GISTIC peaks with a significantly different prevalence across the three stages (yellow: Fisher’s exact test p < 0.05 and green: q < 0.1). On the first, second and third cumulative plots we reported the significant difference between: stable myeloma precursor condition vs. MM, stable myeloma precursor condition vs. progressive myeloma precursor condition and progressive myeloma precursor condition vs. MM, respectively. MGUS: monoclonal gammopathy of undetermined significance, SMM: smoldering multiple myeloma, chr: chromosome.

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