Fig. 5: Landscape of structural variants (SV) in multiple myeloma (MM) and myeloma precursor condition. | Nature Communications

Fig. 5: Landscape of structural variants (SV) in multiple myeloma (MM) and myeloma precursor condition.

From: Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities

Fig. 5

a Prevalence of single and complex SV events across all cases included in this study. PD47563 is a patient with stable myeloma precursor condition with two samples collected at different time points, both reported in this plot (i.e., PD47563a and PD47563c). Blue, purple, and brown x-axis labels represent stable, progressive myeloma precursors and MM respectively. Ins: insertion, TRA: translocation. b Genome-wide density of SV breakpoints across stable, progressive myeloma precursors, and MM. Each patient genome was divided in bins of 1 Mb and, in case of presence of multiple SV breakpoints, only one breakpoint was counted. c Prevalence of 69 known SV hotspots across stable and progressive myeloma precursors, and MM. MGUS: monoclonal gammopathy of undetermined significance, SMM: smoldering multiple myeloma, SD: stable, PD: progressive, in the heatmap Red: mutated; Gray: wild type.

Back to article page