Fig. 6: Timing the acquisition of the first multi-gain event in multiple myeloma (MM) and myeloma precursor conditions. | Nature Communications

Fig. 6: Timing the acquisition of the first multi-gain event in multiple myeloma (MM) and myeloma precursor conditions.

From: Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities

Fig. 6

a Comparison of the patients’ age at the time of sample collection between stable (N = 15), progressive (N = 17) myeloma precursors and MM (N = 80). p values were calculated using the Wilcoxon rank-sum test. b Estimated patient age at the first multi-gain events with 95% confidence of intervals. Blue, purple and brown dots and lines represent stable (N = 7), progressive (N = 11) myeloma precursors, and MM (N = 22) respectively. Gray boxes reflect the sample collection time. c Comparison of estimated patient age at the first multi-gain events between stable, progressive myeloma precursors and MM. p values were calculated using the Wilcoxon rank-sum test. For (a, c) boxplots show the median and interquartile range. MGUS: monoclonal gammopathy of undetermined significance, SMM: smoldering multiple myeloma, SD: stable, PD: progressive.

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