Fig. 5: Significant (p < 0.05) downstream protein abundance and log2(CPM) correlations. | Nature Communications

Fig. 5: Significant (p < 0.05) downstream protein abundance and log2(CPM) correlations.

From: Skeletal muscle transcriptome in healthy aging

Fig. 5

a Distribution of 4281 protein–RNA correlation coefficients. b Scatterplot of the age β-coefficients for the protein–RNA matches limited to the 122 mRNAs significantly associated with age (p-value from two-sided Wald test, unadjusted). c Heat map of 122 mRNAs significantly associated with age and their correlations with proteins. The mRNA with the strongest negative correlation (H2AZ) is shown in the inset (p-value from two-sided Wald test, unadjusted). d Among all the RNAs in the four top 20 lists, ten RNAs were identified to have statistically significant correlations between relative protein abundance and age (red and blue points indicate mRNAs with positive and negative correlations, respectively). Of these ten RNAs, nine had statistically significant correlations between relative protein [log2(Protein Abundance)] and RNA abundance [log2(CPM)] (p-values from two-sided Wald test, unadjusted).

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