Fig. 5: Prophylactic treatment with 6-TG reduces necrotic lesion size in subcutaneous infection. | Nature Communications

Fig. 5: Prophylactic treatment with 6-TG reduces necrotic lesion size in subcutaneous infection.

From: Coagulase-negative staphylococci release a purine analog that inhibits Staphylococcus aureus virulence

Fig. 5

a Representative images showing necrotic skin lesions 4 days post infection with S. aureus ± prophylactic 6-TG treatment. b Quantitation of necrotic skin lesion size 4 days post infection with S. aureus ± prophylactic 6-TG (20 µg) treatment. Results are pooled from two independent experiments with 8–12 lesions per group (n = 4 and 6 animals, respectively). Data are shown as mean ± SD (****p ≤ 0.0001. Two-sided unpaired t-test). c Skin tissue was excised from mice infected with S. aureus 4 days post infection ± prophylactic 6-TG treatment (20 µg) and plated onto TSA to enumerate CFUs. Results are from one experiment with 8–12 lesions per group (n = 4 and 6 animals, respectively). Data are shown as mean ± SD (two-sided unpaired t-test).

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