Table 1 Putative function of gene products in the S. chromogenes 6-TG biosynthetic cluster.

From: Coagulase-negative staphylococci release a purine analog that inhibits Staphylococcus aureus virulence

Protein

Predicted function

e.g., homolog; organism

Confidence (%)

Coverage (%)

TgsA

PLP-dependent cysteine desulfurase

SufS; Bacillus subtilis

100

96

TgsB

Nucleotide alpha hydrolase; sulfur transferase

TtuA; Thermus thermophilus

100

97

TgsC

NUDIX hydrolase family protein; DNA mismatch repair; pyrophosphatase

MutT; Bacillus halodurans

99.9

100

TgsD

Membrane protein; efflux

EmrE; E. coli

100

95

TgsE

NUDIX hydrolase family protein; DNA mismatch repair; 8-oxo-dGTP diphosphatase

MutT; Mycobacterium smegmatis

99.9

89

TgsF

Haloacid dehalogenase-like hydrolase; phosphatase

YfnB; Bacillus subtilis

100

92

  1. Phyre2, the protein homology/analogy Recognition Engine v.2.0, web portal was used to search the protein structure databases for predicting protein structure and function.
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