Fig. 8: miR-135a-5p/Rock2/Add1 signal mediates the synaptic/memory impairments in AD. | Nature Communications

Fig. 8: miR-135a-5p/Rock2/Add1 signal mediates the synaptic/memory impairments in AD.

From: miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease

Fig. 8

In normal conditions (left), miR-135a-5p was transcriptionally regulated by Foxd3 and suppressed the Rock2 expression, which was essential for normal synaptic plasticity. In AD (right), loss of Foxd3 results in the downregulation of miR-135a-5p and the overexpression of Rock2, which in turn caused the hyperphosphorylation of Add1 in the Ser726 site and the aberrant dendritic morphology, as well as the synaptic/memory impairments. Blocking the hyperphosphorylation of Add1 by siP-Add1 partially rescued those abnormalities.

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