Fig. 8: Proposed model.
From: Wobble tRNA modification and hydrophilic amino acid patterns dictate protein fate
Loss of U34-enzymes invariably determines pausing and accumulation of ribosomes on transcripts rich in XAA codons. The result of this pausing on protein expression is determined by the presence of hydrophilic motifs that mediate protein aggregation and subsequent clearance. See text for details.
