Fig. 5: Longevity of HDA mutants is dependent on trehalose metabolism.
From: Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism
A Transcriptome analysis of five carbohydrate metabolism related pathways in hda1Δ, rad50Δ, and sgs1Δ. B RNA level of designated glycogen and trehalose metabolism genes in hda1Δ and tup1Δ, data from Reimand et al.45. C RNA level of designated glycogen and trehalose metabolism genes in hda1Δ and tup1Δ, measured by quantitative real-time PCR. Error bars represent SEM, n = 3. p-value calculated by two-sided T-test, *p < 0.05, **p < 0.01. Exact p-values are GLG1: 0.022; GSY1: 0.007; GSY2: 0.006; GLC3: 0.012; TPS1: 0.002; TPS2: 0.003. D RLS of WT, hda1Δ, UGP1OE, and hda1Δ UGP1OE. E Glycogen and trehalose levels in WT and hda1Δ, with designated time of treatment under MMS. Error bars represent SEM, n = 3. F RLS of WT, hda1Δ, gsy2Δ, and hda1Δ gsy2Δ. G RLS of WT, hda1Δ, tps2Δ, and hda1Δ tps2Δ. H RLS of WT, hda1Δ, tps3Δ, and hda1Δ tps3Δ. I Trehalose levels in WT, UGP1OE, tps2Δ and tps3Δ. Error bars represent SEM, n = 3. Exact p-values are UGP1OE: 0.002; tps2Δ: 0.002 and tps3Δ: 0.50. See also Fig. S3.
