Fig. 1: Structure of tetrameric human MnSOD.
From: Direct detection of coupled proton and electron transfers in human manganese superoxide dismutase
a The active site of MnSOD is within a positively charged cavity formed from two adjacent subunits. The hydrogen bond network is denoted by green dashes and involves residues from both subunits. The inset indicates chain identity where A and B comprise the asymmetric unit while C and D are generated by symmetry. This chain coloring scheme is used in all the figures. Solvent and substrate accessibility is possible only through the ~5 Å gap between His30 and Tyr34. b Side-view of the active site cavity rotated approximately 90° relative to a. Structure is from PDB ID 5VF9 [10.2210/pdb5VF9/pdb]77.
