Fig. 5: The B cell signatures based on the single-cell RNA-seq results are significantly associated with improved survival in TNBC patients and provide better prognostication than classic single B cell markers. | Nature Communications

Fig. 5: The B cell signatures based on the single-cell RNA-seq results are significantly associated with improved survival in TNBC patients and provide better prognostication than classic single B cell markers.

From: Atlas of breast cancer infiltrated B-lymphocytes revealed by paired single-cell RNA-sequencing and antigen receptor profiling

Fig. 5

a Kaplan–Meier survival curves for the overall survival (left panels) and disease-free survival (right panels) of METABRIC TNBC patients according to single gene expression (CD20) or combined gene transcription signatures (naive B cells and memory B cells). The 279 TNBC patients were sorted according to the expression levels of the gene or gene signatures, and the top 33% (n = 92) vs. bottom 33% (n = 92) of patients were used to generate survival curves (“Methods”). The p values were calculated by the two-sided log-rank test. b Prognostic effect of CD20, naive B signature, and memory B signature in METABRIC TNBC patients. Forest plot shows HRs (the center blue squares) and 95% confidence intervals (horizontal ranges) derived from Cox regression survival analyses of disease-free survival in multivariable analyses adjusted for lymph node status, tumor size, age at diagnosis, and histological grade. Data were presented as HR and 95% confidence intervals.

Back to article page