Table 1 Patient demographics of the analyzed study population.

From: Microbiota-based markers predictive of development of Clostridioides difficile infection

Total number of patients

945

Age (median [IQR])

70 [61–79]

Male gender (%)

557 (58.9)

Myocardial infarction (%)

78 (8.25)

Congestive heart failure (%)

134 (14.2)

Peripheral vascular disease (%)

143 (15.1)

Cerebrovascular disease (%)

81 (8.57)

COPD (%)

144 (15.2)

Connective tissue disease (%)

53 (5.61)

Peptic ulcer disease (%)

50 (5.29)

Diabetes mellitus (%)

268 (28.4)

Moderate to severe chronic kidney disease (%)

127 (13.4)

Hemiplegia (%)

16 (1.69)

Leukemia (%)

55 (5.82)

Malignant lymphoma (%)

68 (7.20)

Solid tumor (%)

208 (22.0)

Liver disease (%)

88 (9.31)

AIDS (%)

10 (1.06)

Intestinal obstruction (%)

5 (0.53)

Inflammatory bowel disease (%)

14 (1.48)

Other non-specified comorbidities (%)

538 (56.9)

Has history of CDI (%)

14 (1.48)

Developed CDI within study period (%)

14 (1.48)

Developed AAD within study period (%)

64 (6.77)

Country of origin

France (%)

210 (22.2)

Germany (%)

145 (15.3)

Greece (%)

85 (8.99)

The Netherlands (%)

14 (1.48)

Romania (%)

184 (19.5)

Spain (%)

307 (32.2)

Antibiotic treatment received from D1 to D5

Penicillin + beta-lactamase inhibitor (PBL, %)

194 (20.5)

Other beta-lactam antibiotics (OBL, %)

133 (14.1)

Fluoroquinolones (FQN, %)

63 (6.67)

Combination therapy and other (%)

347 (36.7)

Patients without a D6 sample (%)

208 (22.0)

  1. IQR interquartile range, COPD chronic obstructive pulmonary disease, AIDS acquired immune deficiency syndrome, AAD patients with non-C. difficile antibiotic-associated diarrhea, CDI patients with confirmed C. difficile infection, D1 rectal swab sample collected upon study enrollment, D6 rectal swab collected ~6 days after initiation and at the end of antibiotic treatment.