Fig. 1: Nanoparticle characterization. | Nature Communications

Fig. 1: Nanoparticle characterization.

From: Intratumoral immunotherapy using platelet-cloaked nanoparticles enhances antitumor immunity in solid tumors

Fig. 1

a Characterization of surface markers on platelet membrane, including phosphatidylserine (PS), P-selectin, GPIbα, and αIIbβ3. b, c Quantification of pro-thrombotic platelet-activating molecules thrombin (b) and adenosine diphosphate (ADP, c) in platelet-rich plasma (PRP), platelet lysate, and purified platelet membrane (n = 3, mean + SD). d Average hydrodynamic diameter and polydispersity index (PDI) of bare nanoparticle (NP) cores, uncoated NP-R848, PNP, and PNP-R848 (n = 3, mean + SD). e Zeta potential of bare NP, NP-R848, PNP, and PNP-R848 (n = 3, mean + SD). f, g Transmission electron microscopy visualization of uncoated NP-R848 (f) and coated PNP-R848 (g) with uranyl acetate negative staining (scale bars = 50 nm; repeated 3 times). h Drug release profile from uncoated NP-R848 and coated PNP-R848 over 6 days (3 independent experiments). Source data are provided as a Source Data file.

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