Fig. 3: Relation between IgG response and neutralizing antibodies. | Nature Communications

Fig. 3: Relation between IgG response and neutralizing antibodies.

From: Seroprevalence and correlates of SARS-CoV-2 neutralizing antibodies from a population-based study in Bonn, Germany

Fig. 3

a Individuals with neutralizing antibodies had a significantly higher IgG antibody response as represented by the ELISA IgG ratio (a minus or a plus sign indicates a negative or positive test result, respectively). Each individual measurement is represented by one dot. The red dotted line indicates the threshold for a positive ELISA result. The box-plots indicate the medians (bold horizontal lines) and interquartile ranges (box boundaries), while the whiskers represent 1.5× interquartile ranges. Sample sizes: 23 ELISA+/IFT−/PRNT−, 7 ELISA+/IFT+/PRNT−, and 17 ELISA+/IFT+/PRNT+. P-values were obtained by the two-sided non-parametric Wilcoxon test. b Only in the ELISA+/PRNT+ subgroup there was a significantly higher IgG response with increasing age. The shaded areas around the regression lines represent the 95% confidence intervals of the mean. The red dotted line indicates the threshold for a positive ELISA result. Please refer to the main text for further details. IFT immunofluorescence test, PRNT plaque reduction neutralization test.

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