Fig. 1: Structural comparison of KIR2DL2 in complex with HLA-C*07:02-RL9 and HLA-C*03:04-GL9.
From: Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C
a Overall structure of KIR2DL2 in complex with HLA-C*07:02-RL9. The complex is represented in cartoon format with KIR2DL2 coloured pink, HLA-C*07:02 coloured grey, β2 m coloured orange and the peptide coloured magenta. b Comparison of KIR2DL2 in complex with HLA-C*03:04-GL9 (KIR coloured green) and HLA-C*07:02-RL9 (KIR coloured pink). The relative difference in hinge and twist angles of the KIR is shown. Footprints of KIR2DL2 on HLA-C*07:02-RL9 (c) and HLA-C*03:04-GL9 (d) coloured by domain binding. D1 contacts coloured green, D1-D2 interdomain loop contacts coloured red and D2 contacts coloured orange.
