Fig. 6: Pair feeding abolishes muscle gain in Lcn2-KO mice during cachexia.
From: Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia
a Cumulative food intake after the initiation of cachexia symptoms. N = 5 per group. b Terminal gastrocnemius and c cardiac tissue mass normalized to baseline mass. N = 5 per group for WT sham, Lcn2-KO sham, and Lcn2-KO tumor groups; N = 4 for the WT tumor group. Cumulative food intake data were analyzed by a repeated-measures Two-way ANOVA followed by Bonferroni’s post hoc test. Data presented in b, c were analyzed by a Two-way ANOVA followed by Bonferroni’s post hoc test. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, and ****p ≤ 0.0001. PF pair-fed. All data are expressed as mean ± SEM. Gray = WT sham operation control; black = Lcn2-KO sham operation control; blue = WT KPC-engrafted mice; red = Lcn2-KO KPC-engrafted, pair-fed mice.
