Fig. 7: The estimated proportion of VCAM1+ proximal tubular cells increases in acute and chronic kidney disease. | Nature Communications

Fig. 7: The estimated proportion of VCAM1+ proximal tubular cells increases in acute and chronic kidney disease.

From: Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney

Fig. 7

a, b Deconvolution analysis of bulk RNA-seq mouse kidney IRI dataset (GSE98622) with BisqueRNA. Sham control and IRI (a), or no surgery control (b). c Inter-species data integration was performed between mouse IRI snRNA-seq (GSE139107) and human snRNA-seq with Seurat (left). PT and PT_VCAM1 from human snRNA-seq (middle) are label-transferred from mouse IRI snRNA-seq, and the frequencies of predicted cell types are shown on the heatmap (right). d Deconvolution analysis of bulk RNA-seq TCGA non-tumor kidney data (e) Deconvolution analysis of bulk RNA-seq human diabetic nephropathy (DN) data (GSE142025) with BisqueRNA. Box-and-whisker plots depict the median, quartiles and range. *P < 0.05; **P < 0.01; ***P < 0.005, one-way ANOVA with post hoc Dunnett’s multiple comparisons test. All P values are provided in the Data Source file.

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