Fig. 1: Reaction development.

a Selected drugs featuring a piperidine or pyridine core. b Known strategies to chiral 1,2-dihydropyridines. c Organocatalytic Mannich/Wittig/cycloisomerization sequence to chiral 1,2-dihydropyridines.
a Selected drugs featuring a piperidine or pyridine core. b Known strategies to chiral 1,2-dihydropyridines. c Organocatalytic Mannich/Wittig/cycloisomerization sequence to chiral 1,2-dihydropyridines.