Fig. 1: Case selection criteria and neuropathologic subtyping of AD. | Nature Communications

Fig. 1: Case selection criteria and neuropathologic subtyping of AD.

From: Transcriptomic analysis to identify genes associated with selective hippocampal vulnerability in Alzheimer’s disease

Fig. 1

a Flowchart describing selection criteria of AD cases to obtain frozen hippocampal tissue used to perform RNA-Seq and NanoString studies. AD cases were subtyped using a validated algorithm based on topographic distribution of hippocampal and cortical neurofibrillary tangles13. Brain cartoons illustrate corticolimbic patterns of neurofibrillary tangle burden throughout the brain in each AD subtype, where red indicates a high tangle burden and yellow/tan indicates a low tangle burden. b Overview of sample size for RNA-Seq and NanoString cohorts organized by AD subtype and control classification. Note: Cohort expansion for NanoString included all RNA-Seq cohort samples. AD, Alzheimer’s disease; DV300, distribution value over 300 base pairs; HpSp, hippocampal sparing; Limbic, limbic predominant; NFT, neurofibrillary tangle; RIN, RNA integrity number; RNA-Seq, RNA sequencing.

Back to article page