Fig. 5: Comparisons of Gq-coupled H1R with Gs- and Gi-coupled receptors. | Nature Communications

Fig. 5: Comparisons of Gq-coupled H1R with Gs- and Gi-coupled receptors.

From: Cryo-EM structure of the human histamine H1 receptor/Gq complex

Fig. 5

a A comparison of the αH5 engagement between GLP-1R/Gs (PDB 5VAI) and the H1R/Gq complex. The dashed arrow shows the additional outward displacement of the TM6 of GLP-1R. b A comparison of the Gβ interactions between the CTR/Gs (PDB 5UZ7). c A comparison of the ICL2 interaction between the DRD2/Gi (PDB 6VMS) and the H1R/Gq complex.

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