Fig. 2: Multiomic characterization of subtype-specific super-enhancers.
From: Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling
a Heatmap compares H3K27ac enrichment patterns between TNBC-specific SEs and non-TNBC-specific SEs across TNBC and non-TNBC cell lines. b A genome-wide overview of the loci and co-occurrence frequencies of identified TNBC-specific SEs in TNBC cell lines. Oncogenes FOXC1, MET and MYC were indicated. c Genome browser plot illustrates TNBC-specific SE detected in the upstream region of MET. d Higher enrichment of H3K4me1 signals was observed in TNBC-specific SEs in TNBC cell lines than non-TNBC cell lines, whereas H3K27me3 signals were depleted in TNBC-specific SEs in TNBC cell lines. e Heatmaps illustrate gene expression, DNA methylation, H3K27ac, H3K4me1, H3K4me3, H3K27me3 patterns of cancer-related genes in TNBC cell lines compared to non-TNBC cell lines. In each heatmap, the cell lines were organized by hierarchical clustering, with labels colored in orange and blue highlighting TN lines and non-TNBC lines, respectively.
