Fig. 6: PRNPs are selectively distributed in OCs and inflammatory macrophages in arthritic joints of rats with advanced arthritis. | Nature Communications

Fig. 6: PRNPs are selectively distributed in OCs and inflammatory macrophages in arthritic joints of rats with advanced arthritis.

From: Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis

Fig. 6

Confocal images showing the distribution of different DiD formulations in synovial macrophages (a) and OCs (b) in inflamed joints. Macrophages and OCs were determined by immunofluorescence analysis of CD68 and CD51 (green fluorescence), respectively. (Scale bar = 25 μm) (n = 3 independent animals). DiD 1,1′-dioctadecyl-3,3,3′,3′-tetramethyl indodicarbocyanine, 4-chlorobenzenesulfonate salt, DiD-NPs DiD labeled poly (d, l-lactide-co-glycolide) (PLGA) nanoparticles, DiD-RNPs DiD-labeled RGD peptide-modified PLGA nanoparticles, DiD-PRNPs DiD-labeled matrix metalloproteinase 9 (MMP9)-cleavable polyethylene glycol (PEG)- and RGD peptide-modified PLGA nanoparticles.

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