Fig. 9: CEL-PRNPs reverse bone erosion in rats with advanced arthritis. | Nature Communications

Fig. 9: CEL-PRNPs reverse bone erosion in rats with advanced arthritis.

From: Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis

Fig. 9

a Representative micro-CT images of the ankle joints at the endpoint of the experiment from different treatment groups in therapeutic efficacy study (n = 3 independent animals). b Representative micro-CT images of the trabecular in bone and the reconstructed trabecular structure (n = 3 independent animals). c, d Quantitative micro-CT analysis of BMD (c) and BS/BV (d) of the ankle joints at the endpoint of the experiment. Data represent mean ± SD (n = 3 independent animals). Statistical significance was determined by a two-sided Student’s t test. e–g Quantitative micro-CT analysis of trabecular number (Tb.N) (e), trabecular bone thickness (Tb.Th) (f), and decreasing trabecular separation (Tb.Sp) (g). Data represent mean ± SD (n = 3 independent animals). Statistical significance was determined by a two-sided Student’s t test. Anti-TNF anti-TNF (tumor necrosis factor) antibody, CEL celastrol, CEL-NPs CEL-loaded poly (D, L-lactide-co-glycolide) (PLGA) nanoparticles, CEL-RNPs CEL-loaded RGD peptide-modified PLGA nanoparticles, CEL-PRNPs CEL-loaded matrix metalloproteinase 9 (MMP9)-cleavable polyethylene glycol (PEG)- and RGD peptide-modified PLGA nanoparticles.

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