Fig. 2: Moss improves recall without loss of precision on synthetic data.
From: Moss enables high sensitivity single-nucleotide variant calling from multiple bulk DNA tumor samples
a Linear phylogenetic tree with the root representing the normal clone and four additional tumor clones. Edge label indicates number of SNVs (single-nucleotide variants) newly introduced into each tumor clone. The table shows the prevalence of each clone in each sample. b Precision-recall curves of the union of SNVs identified by Strelka2 (light blue) and Mutect2 (light red) when applied independently to samples of a simulated bulk DNA sequencing dataset with 5 samples and 60× coverage, as well as when Moss is applied in conjunction with these methods (blue and red). The dashed lines represent F1 score isolines (i.e., harmonic mean between recall and precision).
