Fig. 5: Moss recovers high-quality somatic variants missed by Strelka2 in a colorectal cancer (CRC) dataset32.
From: Moss enables high sensitivity single-nucleotide variant calling from multiple bulk DNA tumor samples
a Venn diagram comparing the call set of Strelka2 when run in isolation and when run in conjunction with Moss. Moss identifies 49,497 new variants while retaining almost all variants identified by Strelka2. b The number of supporting samples by Moss (x-axis) and the single-sample caller Strelka2 (y-axis) for each variant, showing that Moss increases the number of supporting samples for 23% of variants (52,690 variants) identified by Strelka2, increasing the number of common SNVs (single-nucleotide variants) that are present in at least two samples (Supplementary Fig. 12). c Exposure to mutational signatures of colorectal tumor for the different methods (each signature is represented with a unique color). The identified signatures remain the same.
