Fig. 7: Proposed model for the aberrant chromatin structure of the LMBR1-SHH locus in the acheiropodia patient.

Model of chromatin structure in the LMBR1-SHH locus based on our ChIP-seq and 4C-seq data. CTCF sites are shown as red triangles and the cohesin complex is shown as a green ring. The ZRS is depicted as an orange oval.