Fig. 7: RNA folding and splicing could mediate co-transcriptional suppression of premature cleavage and polyadenylation (a hypothesis).
From: Conserved long-range base pairings are associated with pre-mRNA processing of human genes
A The cleavage and polyadenylation of a structured pre-mRNA is rescued by the co-transcriptional splicing of the intron, while RNA structure stabilizes the molecule through intramolecular base pairings. B In the absence of RNA structure, such a rescue would not happen when splicing has a delay relative to cleavage and polyadenylation. Switching between (A) and (B) depends on the rates of splicing, folding, and RNA Pol II elongation.
