Fig. 4: Static 2D visualization of the seed and variant genes in the interactome.

a The 247 seed and 13 variant genes are scattered across several disconnected subnetworks in the interactome. The largest connected component contains 157 genes (153 seed and 4 variant genes). b Using a Steiner tree approach⁶⁰, we can identify a minimal set of linker genes for integrating all seed and variant genes into a single connected component. The resulting subnetwork consists of N = 334 nodes and M = 1387 links. c Expansion of the subnetwork in (b) with all first neighbors results in N = 10,915 nodes and M = 261,853 links. d Random walk-based interactome neighborhood around the seed genes obtained by including all genes that are ranked above the top three variant genes (N = 4052; M = 118,218). All network visualizations were created using the Cytoscape software.