Table 2 Predictors of gametocyte density on day 14.

From: Higher gametocyte production and mosquito infectivity in chronic compared to incident Plasmodium falciparum infections

Covariate

Difference in log gametocytes/µl on day 14a

Adjusted difference in log gametocytes/µl on day 14b

Incident infection

−4.07 [−5.96, −2.18], p < 0.001

−2.52 [−4.55, −0.50], p = 0.016

Female

−0.95 [−2.30, 0.40], p = 0.163

–

Age

  5–7

0

0

  8–10

−1.75 [−3.30, −0.19], p = 0.028

−2.11 [−3.44, −0.77], p = 0.002

Log total parasite density/µl on day 0 (1 unit increase)

0.38 [0.13, 0.63], p = 0.004

0.52 [0.27, 0.77], p < 0.001

Log total parasite density/µl on day 14 (1 unit increase)

0.10 [−0.14, 0.35], p = 0.411

–

Log PMR (1 unit increase)

1.06 [0.05, 2.07], p = 0.040

1.57 [0.08, 3.07], p = 0.040

Hb g/dl on day 14 (1 unit increase)

0.29 [−0.22, 0.81], p = 0.256

 

Hb genotype

p = 0.931

 

  AA

0

–

  C

0.31 [−1.36, 1.97]

–

  S

0.67 [−1.40, 2.73]

–

  SC

0.52 [−4.85, 5.89]

–

COI on day 0

p = 0.239

 

  1–3

0

–

  4–6

−1.64 [−3.6, −0.40]

–

  7–19

−0.86 [−3.01, −1.30]

–

Aggregate magnitude of antibody response

p = 0.285

 

  Lowest tertile

0

–

  Middle tertile

0.40 [−1.33, 2.14]

–

  Highest tertile

2.27 [−0.57, 5.11]

–

  1. Data on day 14 gametocyte density was available for 65 individuals, 52 with chronic infections and 13 with incident infections. Hb genotype: haemoglobin genotype; COI: complexity of infection (number of parasite clones) on day 0. Aggregate magnitude of antibody response was calculated by ranking each individual according to their combined response to 13 P. falciparum antigens, as described in the ‘Methods’ section.
  2. aAdjusted for whether the infection was incident.
  3. bAdjusted for whether the infection was incident, log total parasite density/µl on day 0, log total parasite multiplication rate (PMR), and age.
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