Fig. 6: Kinetic model of talin-FAK interactions under force. | Nature Communications

Fig. 6: Kinetic model of talin-FAK interactions under force.

From: Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair

Fig. 6

a Schematic of FAK-talin interactions showing unstretched (T) and stretched talin (Tst), free FAK (F), FAK-talin complex (FTst), and phosphorylated FAK-talin complex (pFTst). Governing equations and parameters used in the kinetic model are listed in Supplementary Materials. b–d Solutions for a relative number of (b) stretched talin, (c) FAK-talin complexes, and (d) phosphorylated FAK-talin complexes as a function of applied force (f) for different values of the force coupling factor (α). e–g Solutions for a relative number of (e) stretched talin, (f) FAK-talin complexes, and (g) phosphorylated FAK-talin complexes as a function of applied force (f) for different values of the forward binding rate constant for FAK-talin complex (k3). h–j Solutions for a relative number of (h) stretched talin, (i) FAK-talin complexes, and (j) phosphorylated FAK-talin complexes as a function of applied force (f) for different values of the FAK phosphorylation rate constant (k5).

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