Fig. 7: Transcriptomic analysis in hAβ-KI mice.

Differential gene expression analysis was performed comparing 2 months WT and hAβ-KI mice (a), 2 and 22 months WT mice (b), 2 and 22 months hAβ-KI mice (c) and 22 months WT and hAβ-KI mice (d), differentially expressed gene were selected following p < 0.05 and FDR < 0.1 values (n = 6 in hAβ-KI 22 mo, n = 7 in WT 2 mo and n = 8 in WT 22 mo and hAβ-KI 2 mo). e Heatmap of group d of genes with p < 0.05 and FDR < 0.1 were represented with expression data from the 2 months WT and hAβ-KI mice added. Module eigengene trajectory of green (f), pink (g) and red (h) modules in WT and hAβ-KI mice at 2 and 22 months (n = 6 in hAβ-KI 22 mo, n = 7 in WT 2 mo and n = 8 in WT 22 mo and hAβ-KI 2 mo) (blue = WT 2 mo, light-blue = WT 22 mo, green = hAβ-KI 2 mo and light-green = hAβ-KI 22 mo). Module eigengene trajectory of green (i), red (j) and pink (k) modules in human temporal cortex AD data (²⁸, n = 160 samples) (blue = control and green = AD). Module eigengene trajectory of green (l), red (m) and pink (n) modules in human AD frontal cortex data (⁶⁴, n = 680 samples) (blue = control and green = AD). In all the boxplots, the upper and lower lines represent the 75th and 25th percentiles, respectively, while the center line represents the median (unpaired, two-tailed, t-test *p < 0.05 and ****p < 0.0001 were used). Gene ontology term enrichment for green (o), red (p) and pink (q) modules.