Fig. 3: Mechanisms of DNA unwrapping in nucleosomes with truncated histone tails based on NCPtt145 simulation.
From: Histone dynamics mediate DNA unwrapping and sliding in nucleosomes
Top panel: different DNA unwrapping states. Middle panel: substates within each state showing different conformations of the H3-latch residues interacting with the nucleosomal DNA end and the neighboring DNA gyre. Bottom panel: profile of the extent of DNA unwrapping during MD simulations. Thin semitransparent lines are used to plot instantaneous unwrapping values; thick lines depict smoothed signal with Savitzky-Golay filter using 100 ns window and first-degree polynomial.
