Fig. 7: Bulk RNAseq analysis of tumor tissues. | Nature Communications

Fig. 7: Bulk RNAseq analysis of tumor tissues.

From: Hypothalamic Rax+ tanycytes contribute to tissue repair and tumorigenesis upon oncogene activation in mice

Fig. 7

a–c Principal component (PC) analysis (a), MA plot (b), and volcano plot (c) showing the differential gene expression in ME tissues of control and Rax-CreERT2::BrafV600E mutant mice at 2 months post tamoxifen injection. d A heatmap showing the differential gene expression of control and papillary craniopharyngioma-like tumor tissues. A set of upregulated and downregulated transcription factors, tanycyte markers, and differentiation markers in the mouse papillary craniopharyngioma are highlighted in the table. e, f Gene ontology network analysis of upregulated (e) and downregulated (f) genes in the tumor tissues. The major clusters with different gene ontology are labeled with different colors.

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