Fig. 3: Visualization of kinase-substrate relationships in the CPTAC Ovarian Cancer data. | Nature Communications

Fig. 3: Visualization of kinase-substrate relationships in the CPTAC Ovarian Cancer data.

From: multiSLIDE is a web server for exploring connected elements of biological pathways in multi-omics data

Fig. 3

a Visualization of the subset of kinases-substrate pairs, which are upregulated in the proliferative subtype. The custom “Upload” option is used to select the molecules here. Kinase-substrate interactions were curated from PhosphoSitePlus31, PhosphoNetworks32, and a predictive network inference approach33 to build a kinase-substrate map, which was uploaded into multiSLIDE using the upload network feature. The connecting lines show these curated relationships, with the highlighted (brown) lines connecting cyclin-dependent kinases CDK1 and CDK2 with known substrates. Supplementary Fig. S5 visualizes all the kinases-substrate pairs. b A UMAP visualization of the whole proteomics data for 3329 proteins. The ellipse highlights a cluster of proliferative subtype patients in the protein data. c A UMAP visualization of the whole phosphoproteome data for 5746 phosphosites. The ellipsis highlights a cluster of proliferative subtype patients in the phosphoproteome data.

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