Fig. 4: Visualization of plasma proteins and microRNAs associated with insulin resistance.

Shown in the heatmap are the molecules matched by the keywords: metabolism, inflammatory response, glucose transport, and lipid homeostasis are visualized here after filtering by Mann–Whitney U-test (p value ≤ 0.05 followed by FDR 5%). Proteins and miRNA are independently clustered using correlation distance (1 minus Pearson correlation) and complete linkage function. The relationships between miRNA family names and their target proteins are extracted from TargetScanMap⁵⁰. The original list of 414 proteins and 69 miRNAs, before filtering, is shown in Supplementary Fig. S7.