Fig. 1: Development of site-specific N-terminal protein modification via quinone-mediated transamination.
From: Modification of N-terminal α-amine of proteins via biomimetic ortho-quinone-mediated oxidation
a Natural catalytic cycle of CuAOs; b Oxidation of primary amines with ortho-quinone to form imines; c Biomimetic quinone-mediated transamination inspired by CuAOs. the quinones may be suitable reagents for the selective and efficient oxidation of the N-terminal α-amines of proteins to aldehyde or ketone with fast kinetics as well as a wide scope of amino acids.
