Fig. 6: Late-stage modification of MIP-1β proteins via quinone-mediated selective oxidation of N-terminal amine. | Nature Communications

Fig. 6: Late-stage modification of MIP-1β proteins via quinone-mediated selective oxidation of N-terminal amine.

From: Modification of N-terminal α-amine of proteins via biomimetic ortho-quinone-mediated oxidation

Fig. 6

a Reaction scheme for the transamination of MIP-1β protein 29 and 30; b The sequences of protein 29 and 30; c A summary of the transamination/oxime ligation of protein 29 and 30 and the isolated yields for all reactions; d Anti-HIV-1 activity of selected MIP-1β analogs with EC50 < 5000 nM (Error bars represent standard deviation, n = 2 biological independent replicates).

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